标题:Electrochemical deposition to construct a nature inspired multilayer chitosan/layered double hydroxides hybrid gel for stimuli responsive release of protein作者:Zhao, Pengkun; Liu, Youyu; Xiao, Ling; Deng, Hongbing; Du, Yumin; Shi,Xiaowen
来源出版物:JOURNAL OF MATERIALS CHEMISTRY B 卷:3 期:38页:7577-7584 DOI:10.1039/c5tb01056j 出版年:2015
摘要:In this study, we report a single electrodeposition process to fabricate multilayered chitosan/layered double hydroxides (LDHs) hybrid hydrogels for stimuli responsive protein release. LDHs nanoplatelets with a regular hexagonal shape were synthesized by a hydrothermal method, and a model protein, insulin, was adsorbed on the surface of the LDHs (INS-LDHs) via electrostatic interactions. The insulin loading ratio could reach 20% (w/w); the INS-LDHs were characterized by energy dispersive spectrometry (EDS), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TG) and zeta potential measurements. Co-electrodeposition of chitosan and INS-LDHs generated an inorganic and organic composite hydrogel with a multilayered structure, as revealed by scanning electron microscopy (SEM). The hybrid hydrogel dramatically reduced the burst release of insulin from INS-LDHs. Notably, the release of insulin was sensitive to the presence of anions, pH, and external potentials. These results suggest that co-electrodeposition of a stimuli-responsive polymer and nanoplatelets is an alternative and facile method to construct hierarchically structured hybrid hydrogels and demonstrate the great potential of the multilayered structure in drug delivery.
入藏号:WOS:000361835300012
文献类型:Article
语种:English
扩展关键词:LAYERED DOUBLE HYDROXIDE; TARGETED DRUG-DELIVERY; NANOPARTICLES; HYDROGEL; ELECTRODEPOSITION; INTERCALATION; COMPOSITES; ADSORPTION; IBUPROFEN; SYSTEM
通讯作者地址:Shi, Xiaowen;Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.
电子邮件地址:shixwwhu@163.com
地址:[Shi, Xiaowen] Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.
Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430079, Peoples R China.
研究方向:Materials Science
ISSN:2050-750X
eISSN:2050-7518
影响因子(2014):4.726
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