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博士生丁福源的论文在NEW JOURNAL OF CHEMISTRY刊出
发布时间:2015-03-27 09:31:42     发布者:yz     浏览次数:

标题:Electrochemically induced reversible formation of carboxymethyl chitin hydrogel and tunable protein release作者:Ding, Fuyuan; Qian, Xi; Zhang, Qi; Wu, Hongjie; Liu, Youyu; Xiao, Ling;Deng, Hongbing; Du, Yumin; Shi, Xiaowen

来源出版物:NEW JOURNAL OF CHEMISTRY 卷:39 期:2 页:1253-1259 DOI:10.1039/c4nj01704h 出版年:2015

摘要:Carboxymethyl chitin is one of the most important derivatives of chitin that has been widely used in the fields of biomedicine and environmental treatment. In this contribution, carboxymethyl chitin was homogenously synthesized in NaOH-urea aqueous solution for the first time. The product was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), H-1 nuclear magnetic resonance (H-1-NMR), gel permeation chromatography (GPC) and a titration method. Carboxymethyl chitin showed water solubility and cationic sensitivity. Reversible sol-gel transition could be performed by sequentially adding cations and a reducing agent. Further, we demonstrated that the reversible sol-gel transition of carboxymethyl chitin could be controlled on the surface of a stainless steel electrode by using an electrochemical method. Once an anodic signal was imposed to the electrode, sol-gel transition occurred due to the crosslinking of carboxymethyl chitin with Fe2+/Fe3+. The gel formation can be facilely controlled by voltage, concentration of carboxymethyl chitin and deposition time. Protein could be entrapped in the hydrogel simultaneously during the in situ formation of hydrogel. Protein release accelerated when a cathodic signal was imposed due to the electrochemically induced conversion of Fe2+/Fe3+ to Fe. The present result represents a "green'' and simple process to synthesize carboxymethyl chitin and the prepared chitin derivative may have potential applications in electrochemically controlled drug delivery systems.

入藏号:WOS:000349222800059

文献类型:Article

语种:English

扩展关键词:DRUG-DELIVERY APPLICATIONS; TITANIA NANOTUBE ARRAYS; RESPONSIVE CHITIN; AQUEOUS-SOLUTION; IRON; CHITOSAN; FIBERS; FILMS; TEMPERATURE; SYSTEM

通讯作者地址:Shi, Xiaowen; uhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.

电子邮件地址:shixwwhu@163.com

地址:

Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.

Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430079, Peoples R China.

研究方向:Chemistry

ISSN:1144-0546

eISSN:1369-9261

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