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博士生丁福源的论文在SOFT MATTER刊出
发布时间:2015-05-29 09:46:10     发布者:yz     浏览次数:

标题:A dynamic and self-crosslinked polysaccharide hydrogel with autonomous self-healing ability作者:Ding, Fuyuan; Wu, Shuping; Wang, Shishuai; Xiong, Yuan; Li, Yan; Li,Bin; Deng, Hongbing; Du, Yumin; Xiao, Ling; Shi, Xiaowen

来源出版物:SOFT MATTER 卷:11期:20 页:3971-3976 DOI: 10.1039/c5sm00587f 出版年:2015

摘要:Natural polymeric hydrogels with self-healing capability that can recover the functionalities and structures of gels after damage are extremely attractive due to their emerging applications in the biomedical field. Here we report a self-healable polymeric hydrogel by self-crosslinking two natural polymers acrylamide-modified chitin (AMC) containing amino groups and oxidized alginate containing dialdehyde groups. The generation of the self-crosslinked hydrogel relies on the dynamic covalent linkage through Schiff base between the polysaccharide chains. The self-healing capability of the crosslinked hydrogel depends on the molar ratio of AMC and oxidized alginate and the surrounding pH. Under certain circumstances, the damaged hydrogel shows a complete recovery and can be stretched to a favorable extent, which is seldom observed for polysaccharide self-healing hydrogel. Notably, we find that the self-healing ability can be "stored" by freeze-drying and "activated" by rehydration. In addition, we demonstrate that the hydrogel can be used as a soft template to guide the repair of inorganic materials like hydroxyapatite. We anticipate that this self-healable hydrogel consisting of biocompatible and biodegradable polysaccharides can be applied to various biomedical fields.

入藏号:WOS:000354449100003

文献类型:Article

语种:English

扩展关键词:OXIDIZED ALGINATE; POTENTIAL APPLICATIONS; RESPONSIVE CHITIN; SODIUM ALGINATE; DRUG-RELEASE; GELATIN; SCAFFOLDS; CHEMISTRY; OXIDATION; CHITOSAN

通讯作者地址:Shi, Xiaowen; Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.

电子邮件地址:shixwwhu@163.com

地址:

[Ding, Fuyuan; Wu, Shuping; Xiong, Yuan; Deng, Hongbing; Du, Yumin; Xiao, Ling; Shi, Xiaowen] Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.

[Ding, Fuyuan; Wu, Shuping; Xiong, Yuan; Deng, Hongbing; Du, Yumin; Xiao, Ling; Shi, Xiaowen] Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan

430079, Peoples R China.

[Wang, Shishuai; Li, Yan; Li, Bin] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China.

研究方向:Chemistry; Materials Science; Physics; Polymer Science

ISSN:1744-683X

eISSN: 1744-6848

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