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博士生杨晨,施晓文的论文在CARBOHYDRATE POLYMERS刊出
发布时间:2022-09-02 15:28:06     发布者:易真     浏览次数:

标题: Electrodeposition induced covalent cross-linking of chitosan for electrofabrication of hydrogel contact lenses

作者: Yang, C (Yang, Chen); Wang, MY (Wang, Manya); Wang, W (Wang, Wei); Liu, HY (Liu, Hongyu); Deng, HB (Deng, Hongbing); Du, YM (Du, Yumin); Shi, XW (Shi, Xiaowen)

来源出版物: CARBOHYDRATE POLYMERS : 292 文献号: 119678 DOI: 10.1016/j.carbpol.2022.119678 出版年: SEP 15 2022

摘要: To meet the requirement of personalization, there is an urgent need to develop a simple, efficient and versatile manufacturing method for customized contact lens manufabrication. Here, we report a novel electrofabrication methodology (i.e., electrodeposition) for the fabrication of hydrogel contact lenses, which can induce covalent cross-linking between chitosan and epichlorohydrin simultaneously. The transmittance and toughness of hydrogels are improved by electrochemical cross-linking without affecting their oxygen permeability. Furthermore, the geometry of the chitosan based hydrogel contact lenses can be customized simply by the electrode template, and its characteristics can be regulated by electrical signals and electrochemical cross-linking. The electrodeposited hydrogel contact lenses have good optical properties, mechanical properties and biocompatibility, and their anti-adhesion properties to Staphylococcus aureus are close to commercial contact lenses. This work reveals the mechanism of electrochemical cross-linking between chitosan and epichlorohydrin and provides an alternative method for contact lens fabrication.

作者关键词: Chitosan; Epichlorohydrin; Electrodeposition; Electrochemical cross-linking; Hydrogel; Contact lenses

地址: [Yang, Chen; Wang, Manya; Liu, Hongyu; Deng, Hongbing; Shi, Xiaowen] Wuhan Univ, Hubei Engn Ctr Nat Polymers based Med Mat, Sch Resource & Environm Sci, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430079, Peoples R China.

[Wang, Wei] Wuhan Univ, Inst Hepatobiliary Dis, Transplant Ctr, Hubei Key Lab Med Technol Transplantat,Zhongnan Ho, Wuhan 430071, Peoples R China.

通讯作者地址: Shi, XW (通讯作者)Wuhan Univ, Hubei Engn Ctr Nat Polymers based Med Mat, Sch Resource & Environm Sci, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430079, Peoples R China.

电子邮件地址: shixw@whu.edu.cn

影响因子:10.723

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