标题：Preparation, characterization and antimicrobial activity of 6-amino-6-deoxychitosan
作者：Yang, JH (Yang, Jianhong); Cai, J (Cai, Jun)2; Hu, Y (Hu, Ying); Li, DL (Li, Dinglong); Du, YM (Du, Yumin)
来源出版物：CARBOHYDRATE POLYMERS 卷：87 期：1 页：202-209 出版年：JAN 4 2012
摘要：6-Amino-6-deoxychitosans with molecular weights from 0.23 x 10(4) to 1.41 x 10(4) and degree of substitution from 0.85 to 0.96 were prepared via N-phthaloylation, tosylation, azidation, hydrazinolysis and reduction of azide groups. Their structures were characterized by FT-IR, (1)H NMR, (13)C NMR, gel permeation chromatography (GPC) and elemental analysis. The antimicrobial activities of 6-amino-6-deoxychitosans against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Aspergillus niger were investigated. The results showed that 6-amino-6-deoxychitosans had a wide spectrum of effective antimicrobial activities. Compared with chitosan, 6-amino-6-deoxychitosans had much better antimicrobial activities. Their minimum inhibitory concentrations (MICs) were between 0.025% and 0.1% (w/v) in acetic/sodium acetate solution with different pH from 5.4 to 7.5. 6-Amino-6-deoxychitosans could also inhibit growth of bacteria tested in distilled water under pH 6.6-8.45. The antimicrobial mechanism was complex and the positive charge on the amino groups was not the sole factor resulting in the antimicrobial activities.
作者关键词：Chitosan; 6-Amino-6-deoxychitosan; Preparation; Antimicrobial activity
扩展关键词：GRAM-NEGATIVE BACTERIA;ANTIBACTERIAL ACTIVITY; CHEMICAL-MODIFICATIONS;QUATERNARY AMMONIUM;CHITOSAN; SUBSTITUTION; ARGININE; CHLORIDE; CARRIER; CELLS
通讯作者地址：Yang, JH (通讯作者),Changzhou Univ, Dept Environm Engn, Sch Environm & Safety Engn, Changzhou 213164, Peoples R China
[Yang, Jianhong]Changzhou Univ, Dept Environm Engn, Sch Environm & Safety Engn, Changzhou 213164, Peoples R China ;Hubei Univ Technology, Key Lab Fermentat Engn, Minist Educ, Wuhan 430068, Peoples R China
[Cai, Jun] Hubei Univ Technology, Key Lab Fermentat Engn, Minist Educ, Wuhan 430068, Peoples R China
[Hu, Ying]Hubei Univ Technology, Key Lab Fermentat Engn, Minist Educ, Wuhan 430068, Peoples R China
[Li, Dinglong] Changzhou Univ, Dept Environm Engn, Sch Environm & Safety Engn, Changzhou 213164, Peoples R China
[Du, Yumin]Wuhan Univ, Dept Environm Sci, Coll Resource & Environm Sci, Wuhan 430079, Peoples R China
学科类别：Chemistry; Polymer Science
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